AlphaTauri will run rookie Isack Hadjar in place of Yuki Tsunoda during Friday Practice 1 for the Mexican Grand Prix.
All teams are required to run drivers with two or fewer races of experience for two first practice sessions across the season.
Although De Vries counted as one of the rookie FP1 outings in Bahrain for AlphaTauri, Liam Lawson did not because he was driving the same car as De Vries and each side of the garage needs to give up one session.
The French-Algerian driver currently races in F1 feeder series Formula 2, and sits in 14th in the championship with two races left in Abu Dhabi.
Hadjar will also get to experience the Red Bull RB19 at Abu Dhabi in one of the practice sessions.
It will not be the only team making use of the regulation, with Alpine also set to run reserve driver Jack Doohan. He will take to the wheel of the A523 for the first of two outings at Mexico and Abu Dhabi.
"We're pleased to announce F2 driver Isack Hadjar is set to get behind the wheel in FP1 this weekend," said the AlphaTauri in a statement.
"He'll be jumping into Yuki's seat to set some laps in Mexico."